In 2016, Gautam performed Pulkit Samrat's love fascination with two romances–Divya Khosla Kumar's Sanam Re and Vivek Agnihotri's Junooniyat. In the former, she performed a high-school woman who falls in deep love with Samrat's character, and in the latter, she shown a Punjabi woman who falls deeply in love with an army officer. Equally Sanam Re and Junooniyat were professional failures.[23]
These year, Gautam collaborated with Hrithik Roshan on Sanjay Gupta's revengeful romantic thriller Kaabil (2017), which tells the story of a blind person who avenges the rape of his blind wife. The movie, as well as her performance, acquired blended opinions and the movie appeared as an economic success, getting ₹1.96 billion (US$28 million) worldwide.
Later in 2017, Gautam highlighted quickly in Ram Gopal Varma's political thriller Sarkar 3, the next sequel of Varma's Sarkar business, Yami Gautam alongside Amitabh Bachchan, Jackie Shroff, Manoj Bajpayee, and Amit Sadh. Sarkar 3 unsuccessful to accomplish well at the package office. Gautam's next discharge was the Shree Narayan Singh directed-social problem dramedy Batti Gul Meter Chalu (2018), where she played a attorney along with Shahid Kapoor, Shraddha Kapoor, and Divyendu Sharma. The film was a commercial failure.
Gautam's greatest achievement came in 2019 when she appeared in Aditya Dhar's military activity thriller film Uri: The Surgical Strike, alongside Vicky Kaushal, Paresh Rawal, Mohit Raina, and Kirti Kulhari. On the basis of the 2016 Uri assault, Gautam represented Pallavi Sharma, a nurse-turned-an intelligence officer. Upon release, the film obtained combined opinions and emerged as one of many highest-grossing Indian films ever, grossing over ₹3.36 thousand (US$54 million) worldwide. Her performance was significantly praised. She reunited with Khurrana in Amar Kaushik's comedy-drama Bala, a satire on physical attractiveness, which was released on 7 December 2019. The movie surfaced as a crucial and commercial accomplishment and her portrayal of Tiktok celebrity Pari Mishra was acknowledged by critics.
By July 2020, she seemed in the movie Ginny Weds Sunny other Vikrant Massey directed by debutant Puneet Khanna and created by Vinod Bachchan, which can be obtained for streaming on Netflix from 9 July 2020.[24]As of February 2021, Gautam began firing for a cultural comedy movie Dasvi, produced by Dinesh Vijan's Maddock Films and Jio Studios, along with Abhishek Bachchan and Nimrat Kaur.[25] Gautam is likewise observed essaying the role of Naina Jaiswal, a playschool teacher who requires 16 kids as hostages in Behzad Khambata's thriller A Thursday, along side Neha Dhupia and Atul Kulkarni.[26] Gautam in addition has shot for Pavan Kirpalani's horror humor Bhoot Authorities, co-starring Saif Ali Khan, Arjun Kapoor and Jacqueline Fernandez.[27] Gautam has also determined to look as character in Aniruddha Roy Chowdhary's untitled social drama.[28]